Plamed | Combining advanced formulation science, molecular engineering, and biotechnology to develop high-performance functional ingredient solutions.
Using an ex vivo human skin model, the study evaluated eight collagen markers, two key structural proteins, and advanced glycation end products (AGEs) before and after treatment. The results clearly demonstrated the proven anti-wrinkle and anti-glycation efficacy of PMAnti-AGEs® Silibinin80 at concentrations of 0.05% and 0.2%, providing reliable scientific validation for skincare applications.
ECM-focused anti-aging research is becoming a major direction in the cosmetic ingredient industry, attracting increasing attention from global skincare brands and laboratories.
Our systematic ECM validation helps distributors stay ahead of next-generation anti-aging trends with stronger scientific positioning.
Validated using ex vivo human skin instead of conventional 3D skin models.
Traditional anti-aging studies often focus only on cellular activity, while overlooking the surrounding extracellular environment.
This research highlights the importance of ECM structural remodeling in skin aging, aligning with advanced anti-aging evaluation standards.
PMAnti-AGEs® Silibinin80 was found to support collagen regeneration from within the skin structure rather than relying on external collagen supplementation.
This provides a more fundamental approach to long-term anti-aging support.
Two concentrations were evaluated: 0.05% and 0.2%.
The concentration-dependent results provide:
