- Package: 10g in a pharmaceutical bottle with built-in sterile aluminum foil seal.
- Storage: Store the product in a sealed container at 2-8°C.
Plamed Vision: Become the leader of natural cosmetic ingredients for sensitive skin.
Palmitoyl Tetrapeptide-7, also known as Tetrapeptide-7 or anti-inflammatory tetrapeptide, is the most widely used anti-inflammatory and repairing signaling peptide in the global high-end cosmetics industry. It is a benchmark active ingredient for anti-aging of sensitive skin and anti-inflammatory repair of acne-prone skin. Currently, compliant production of cosmetic-grade Palmitoyl Tetrapeptide-7 is primarily via chemical synthesis. Plamed adopts solid-phase peptide synthesis to manufacture this ingredient, enabling stable production of highly active pure powder raw materials with HPLC purity ≥98.0%. The internal control standard for active peptide content is ≥85.0%, and batch measured values can reach 94.0%.
Plamed has built a differentiated advantage of international comprehensive control of total chlorine content, defining raw material purity and formula compatibility by “chlorine content”. We directly measure total chloride ion residues in raw materials, providing accurate and unambiguous data on non-active ion residues, in line with USP/EP pharmacopoeia standards. This helps formulators accurately assess the potential impact of raw materials on the formula system, greatly improving formula compatibility and development efficiency. The measured chlorine content of the product is 3.7%, far below the internal control standard of ≤8.0%, effectively filling the quality control blind spot of conventional industry testing.
Core biological activity of Palmitoyl Tetrapeptide-7: It targets the inhibition of excessive release of inflammatory mediators (such as pro-inflammatory factor IL-6), cuts off the signal transduction of chronic skin micro-inflammation, and inhibits the overexpression of matrix metalloproteinases (MMPs). At the same time, it promotes fibroblasts to synthesize Type I/III collagen, fibronectin and glycosaminoglycans, fundamentally reducing collagen degradation and redness/sensitivity caused by inflammation, acting as an anti-inflammatory stabilizer for the skin microenvironment. It also improves skin microcirculation, reduces vascular permeability and tissue fluid exudation.
Therefore, it has core skincare benefits including anti-inflammation and soothing, anti-aging and wrinkle reduction, barrier strengthening and photoaging repair. Cosmetics containing this ingredient can improve skin sensitivity and redness, dry lines and fine wrinkles, sagging, and damaged barrier. It is widely used in sensitive skin repair, high-end anti-aging and anti-inflammatory repair cosmetics.
| Product Name | CAS | INCI | |
| Palmitoyl Tetrapeptide-7 | 221227-05-0 | Palmitoyl Tetrapeptide-7 | |
| Molecular Formula | Molecular Weight | Molecular Structure | |
| C34H62N8O7 | 694.8g/mol |  |
|
| Product ID | Specification | Minimal Package | MOQ |
| PMKZ2901 | Purity ≥98.0% | 10g | 10g |
Palmitoyl Tetrapeptide-7 is derived from chemical synthesis, which is mainly divided into two categories: solid-phase peptide synthesis (SPPS) and liquid-phase peptide synthesis (LPPS).
Plamed has achieved multiple breakthroughs in international total chlorine content quality control, high purity and high active peptide content, and ultra-low impurity residues, which can fully meet the compliance, efficacy and global promotion requirements of high-end cosmetic ingredients.
| Chemical Synthesis | ||
| Production method | Solid-phase peptide synthesis | Liquid-phase peptide synthesis |
| Specific process | Raw materials-Synthesis-Purification- Drying -Packaging | Using a pure liquid-phase system as the reaction environment, the final product is obtained through multi-step amino acid coupling, deprotection, stepwise extraction and purification, and freeze-drying refinement. |
| Advantages | • High actual active ingredient content: HPLC purity≥98%, active peptide content internal control≥85%, measured up to 94%, far exceeding industry averages;
• Low impurities, high stability: extremely low moisture and chlorine impurities, more stable and not easy to degrade; • Fully controlled production process: produces 100% pure powdered active ingredients with no solvent dilution, enabling more precise formula addition. |
Low raw material costs and high flexibility for small-batch custom synthesis, suitable for the synthesis of short peptides and small-molecule fragments. |
| Disadvantages | The synthesis cost is higher than that of liquid-phase method, and the technical requirements are high. | The synthesis process is complex, purity control is difficult, and the cost of large-scale production is high. |
| TEST ITEMS | SPECIFICATION |
| Purity | ≥98.0% HPLC |
| Peptide content | ≥85.0% HPLC |
| Organoleptic | |
| Appearance | Powder |
| Color | White to off-white |
| Odor | Characteristic |
| Physical Characteristics | |
| Chloride content | ≤8.0% |
| Water content | ≤8.0% |
| Heavy Metal | |
| Pb | ≤10ppm |
| As | ≤2ppm |
| Hg | ≤1ppm |
| Cd | ≤5ppm |
| Microorganism Test | |
| Total plate count | ≤1000cfu/g |
| Yeast & mold count | ≤100cfu/g |
Palmitoyl Tetrapeptide-7 is a classic anti-inflammatory signaling peptide that can precisely block the activation of inflammatory signaling pathways. Studies have shown that it can effectively inhibit the overexpression and release of core pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), thereby blocking the cascade amplification reaction of inflammatory signals. At the same time, it inhibits mast cell degranulation, reduces histamine release, lowers skin hypersensitivity, quickly relieves sensitive discomforts such as redness, stinging and dry itching, and fundamentally improves the problem of recurrent inflammation in sensitive skin. It is a rare peptide raw material with dual anti-inflammatory and anti-aging effects.
One of the core causes of skin aging is the continuous degradation of collagen caused by chronic inflammation. Palmitoyl Tetrapeptide-7 achieves root-cause anti-aging through the dual pathways of “anti-inflammation & promotion”: on the one hand, it inhibits the overexpression of matrix metalloproteinases (MMP-1, MMP-3), which are key substances that decompose collagen and elastic fibers. Inhibiting their activity is equivalent to reducing the loss of support structures and the degradation of collagen and elastic fibers from the source. On the other hand, it can create a microenvironment conducive to dermal regeneration, promote the proliferation of skin fibroblasts, up-regulate the synthesis of Type I/III collagen, fibronectin and glycosaminoglycans (such as hyaluronic acid), and increase the thickness of the dermis. Combining “reducing loss” and “increasing production”, it can also synergize with Palmitoyl Tripeptide-1 to promote collagen production, help fill fine lines and depressions formed by collagen loss, improve skin sagging, enhance skin firmness and elasticity, and achieve root-cause anti-aging intervened from the source of inflammation.
Through efficient anti-inflammation, Palmitoyl Tetrapeptide-7 eliminates the continuous attack of inflammatory factors on the skin barrier structure and creates a stable internal environment for barrier self-repair. More importantly, cell experiments show that it can promote the healthy differentiation of keratinocytes and up-regulate the expression of key structural proteins of the stratum corneum such as filaggrin and loricrin. These proteins are important components of the skin’s “brick and mortar structure”, and the increase in their content directly means the strengthening of the barrier structure. The strengthened physical barrier can lock moisture more effectively, which is often manifested in a significant reduction in transepidermal water loss (TEWL) values in clinical evaluations, improving the skin’s resistance to external stimuli, and perfectly meeting the repair needs of damaged barrier skin.
Total chlorine content detection: Detect all chlorine-containing compounds without risk of missed detection.
Objective and transparent data: Provide the actual residual amount of chloride ions (3.7%) instead of converted values.
Palmitoyl Tetrapeptide-7 can achieve significant anti-inflammatory and repair effects with low addition dosage, and is widely used in a full range of skincare products such as sensitive skin repair essence/cream, high-end anti-aging and wrinkle reduction products, eye essence/eye cream, post-aesthetic treatment care products, anti-photoaging sunscreen/essence, moisturizing and soothing mask/essence.
| Product and specification | Reference Dosage |
| Palmitoyl Tetrapeptide-7 (Purity ≥98.0%) | 0.01-0.1% |
Notes:
Application Cases in Major Global Cosmetic Brands
| Country | Brand | Product |
| China | PROYA | Energizing Fresh Anti-Wrinkle Firming Eye Cream |
| PECHOIN | Initial Skin Energizing Anti-Wrinkle Essence Cream | |
| USA
|
LA MER | The Lifting Firming Night Cream, The Eye Concentrate |
| Elizabeth Arden | RETINOL + HPR Ceramide Capsules Line Erasing Night Serum | |
| France
|
Clarins | Double Serum Complete Age Control Concentrate |
| L’Oréal Paris | Age Perfect Nectar Collagen Nourishing Cream, Age Perfect Nectar Collagen Emulsion | |
| CHANEL | N°1 DE CHANEL SÉRUM REVITALISANT AU CAMÉLIA ROUGE | |
| Japan | Shiseido | Benefiance Wrinkle Smoothing Eye Cream |
Plamed focuses on natural cosmetic ingredients for more than 10 years. We have founded four subsidiary companies, which respectively develops different kinds of cosmetic raw material. Plamed is a company whose CEO is designated as the first secretary general of Shaanxi Plant Extraction Association.
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