Package: 10g in a pharmaceutical bottle with a built-in sterile aluminum foil seal.
Storage: Store the product in a sealed container at 2-8°C.
Plamed Vision: Become the leader of natural cosmetic ingredients for sensitive skin.
Palmitoyl Pentapeptide-4, also known as pentapeptide or base peptide, is a classic signaling peptide composed of palmitic acid and five amino acids. It is widely recognized as a benchmark ingredient for collagen stimulation in the anti-aging industry. Currently, the compliant production of cosmetic-grade Palmitoyl Pentapeptide-4 is primarily produced via chemical synthesis. Plamed employs a peptide synthesis method to manufacture this ingredient, enabling the stable production of a highly active, pure powder product with purity ≥98.0% HPLC and a measured active peptide content of ≥91% (industry-leading). It features extremely low levels of inactive impurities (acetic acid/water), strong batch consistency, and offers the core advantages of high activity and high compatibility; Additionally, the product requires storage at only 2-8°C, eliminating the need for a -20°C ultra-low temperature cold chain, which significantly reduces warehousing and transportation costs. Core biological activity of Palmitoyl Pentapeptide-4: It precisely mimics the C-terminal signal sequence of Type I collagen, activating collagen synthesis in dermal fibroblasts and significantly upregulating the gene and protein expression of Type I/III collagen, elastin, fibronectin, and glycosaminoglycans; while simultaneously promoting the proliferation and differentiation of keratinocytes, strengthening the skin barrier structure, and reducing transepidermal water loss. Consequently, it offers skincare benefits including root-cause anti-aging and wrinkle reduction, barrier repair, repair of photo-damage, and long-lasting hydration. Cosmetics containing this ingredient can improve facial dry lines and fine wrinkles, skin sagging and dehydration, damaged skin barrier, and dullness caused by photoaging, helping the skin regain a firm, plump, and resilient youthful appearance. It is widely used in high-end cosmetics targeting anti-aging, wrinkle reduction, firming and repair, and skin barrier strengthening.
| Product Name | CAS | INCI | |
| Palmitoyl Pentapeptide-4 | 214047-00-4 | Palmitoyl Pentapeptide-4 | |
| Molecular Formula | Molecular Weight | Molecular Structure | |
| C39H75N7O10 | 802.05g/mol |  |
|
| Product ID | Specification | Minimal Package | MOQ |
| PMKZ2801 | Purity ≥98.0% | 10g | 10g |
Palmitoyl pentapeptide-4 is derived from chemical synthesis, which is primarily divided into two categories: solid-phase peptide synthesis (SPPS) and liquid-phase peptide synthesis (LPPS). Through comprehensive process optimization, Plamed has achieved breakthroughs in higher active peptide content, lower levels of inactive impurities, and superior product stability, perfectly meeting the compliance, efficacy, and cost control requirements for high-end cosmetic ingredients.
| Chemical Synthesis | ||
| Production method | Solid-phase peptide synthesis | Liquid-phase peptide synthesis |
| Specific process | Raw materials — Synthesis —Purification — Drying — Packaging | Using a pure liquid-phase system as the reaction environment, the final product is obtained through multi-step amino acid coupling, deprotection, stepwise extraction and purification, and freeze-drying. |
| Advantages | High actual active ingredient content: purity≥98% HPLC, and measured active peptide content ≥91%, far exceeding industry averages;
Low impurities, high stability: Extremely low levels of impurities such as acetic acid and moisture, resulting in greater stability and resistance to degradation; Fully controlled production process: Produces 100% pure powdered active ingredients with no solvent dilution, enabling more precise formulation. |
With low raw material costs and high flexibility for small-batch custom synthesis, this method is well-suited for the synthesis of short peptides and small-molecule fragments. |
| Disadvantages | The production costs are relatively high, and the process is technically demanding. | The synthesis process is complex, purity control is challenging, and the cost of large-scale production is high. |
| TEST ITEMS | SPECIFICATION |
| Purity | ≥98.0% HPLC |
| Peptide content | ≥80.0% HPLC |
| Organoleptic | |
| Appearance | Powder |
| Color | White to off-white |
| Odor | Characteristic |
| Physical Characteristics | |
| Water content | ≤8.0% |
| Acetic acid content | ≤15.0% |
| Heavy Metal | |
| Pb | ≤10ppm |
| As | ≤2ppm |
| Hg | ≤1ppm |
| Cd | ≤5ppm |
| Microorganism Test | |
| Total plate count | ≤1000cfu/g |
| Yeast & mold count | ≤100cfu/g |
Palmitoyl pentapeptide-4 is a classic signaling peptide whose core sequence (KTTKS) precisely mimics the C-terminal peptide signal produced by the hydrolysis of human skin type I collagen. Its core mechanism lies in transmitting the biological signal to “synthesize new collagen” to dermal fibroblasts. In vitro studies have confirmed that its active form, C16-KTTKS, effectively stimulates human dermal fibroblasts to produce collagen. Further gene expression studies show that treatment with palmitoyl pentapeptide-4 upregulates the gene expression of type I collagen (COL1A1) in human dermal fibroblasts. By activating collagen synthesis pathways such as TGF-β/Smad, it promotes the synthesis and secretion of extracellular matrix (ECM) components—including Type I and Type III collagen, elastin, and fibronectin-at the source. This increases the thickness and density of the dermis, effectively filling in fine lines and dry lines, improving skin laxity, and enhancing skin firmness and elasticity.
Ultraviolet (UV) light-induced photoaging is a key external factor leading to collagen degradation, wrinkles, and skin laxity. Palmitoyl pentapeptide-4 has demonstrated clear efficacy in improving photoaging. In animal models exposed to UVB radiation, studies using it as a positive control have found that it effectively protects the skin. Its mechanism of action is associated with the inhibition of UV-induced overexpression of matrix metalloproteinases (such as MMP-1 and MMP-3), thereby reducing the degradation of collagen and elastic fibers. At the same time, it helps scavenge excess reactive oxygen species (ROS) generated by UV radiation, alleviates oxidative damage, and delays the appearance of signs of photoaging.
In addition to replenishing structural proteins, palmitoyl pentapeptide-4 also enhances the skin’s natural ability to retain moisture. Studies have shown that it promotes the gene expression of hyaluronan synthase (HAS1) in human dermal fibroblasts. Hyaluronic acid and glycosaminoglycans (GAGs) are key moisture-retaining components in the dermis that can bind large amounts of water. By promoting the synthesis of these endogenous moisturizing factors, palmitoyl pentapeptide-4 increases skin hydration and moisture levels from within the dermis. Combined with its ability to repair the skin barrier and reduce transepidermal water loss, it achieves a dual moisturizing effect of “endogenous hydration” and “exogenous moisture retention,” providing long-lasting relief from dry and rough skin.
Its potential to promote tissue regeneration has also been demonstrated in wound healing models. Animal studies comparing the effects of ointments and patches containing palmitoyl pentapeptide-4 showed that both significantly accelerated wound closure, improved collagen density, and promoted angiogenesis and epithelial regeneration. Notably, patches containing this peptide also performed exceptionally well in promoting epithelial regeneration.
Palmityl Pentapeptide-4 delivers significant collagen-boosting effects even at low concentrations and is widely used in a full range of skincare products, including high-end anti-aging and wrinkle-reducing serums and creams, firming eye creams, gentle anti-aging products for sensitive skin, post-aesthetic treatment care products, sunscreens and serums that combat photoaging, and moisturizing and firming lotions and masks.
| Product and specification | Reference Dosage |
| Palmitoyl Pentapeptide-4 (purity≥98.0%) | 0.01-0.1% |
Note：
Palmitoyl Pentapeptide-4 application cases in major cosmetic brands in the world:
| Country | Brand | Product |
| China | PROYA | Firming & Moisturizing Essence
Energizing Fresh Anti-Wrinkle Essence |
| Winona | Anti-Aging Wrinkle Smoothing Eye Essence | |
| MARUBI | Multi-Peptide Firming Anti-Wrinkle Plumping Eye Cream Multi-Peptide Firming Anti-Wrinkle Essence Eye Mask |
|
| South Korea | BOH (Bio Heal Boh) | PANTHECELL Repair Cica Cream Mist |
| Ongredients | Skin Barrier Calming Lotion | |
| USA | Olay | Peptide Firming Light Moisturizing Cream Peptide Firming Nourishing Oil Cream |
| Elizabeth Arden | Ceramide Plump Perfect Double Chamber Mask | |
| Cosmetic Skin Solutions | Olive & Centella Asiatica Soothing Serum | |
| Japan | SK-II | SKINPOWER ADVANCED CREAM |
| Cosme Decorte | AQ LOTION |
Package: 10g in a pharmaceutical bottle with a built-in sterile aluminum foil seal.
Storage: Store the product in a sealed container at 2-8°C.
Plamed focuses on natural cosmetic ingredients for more than 10 years. We have founded four subsidiary companies, which respectively develops different kinds of cosmetic raw material. Plamed CEO is designated as the first secretary general of Shaanxi Plant Extraction Association.
As a professional Palmitoyl Pentapeptide-4 manufacturer, Plamed have been constantly upgrading the production process. We firmly believe that good Palmitoyl Pentapeptide-4 and good Palmitoyl Pentapeptide-4 price will help customers make good terminal products and help customers win a lasting and broad market.
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