Package: 10g bottle packaging, with a sterile aluminum foil seal inside the bottle mouth.
Storage: Store in cool and dry place at temperature 2 to 8℃, keep away from strong light. Use it as soon as possible after unpacking.
Plamed Vision: Become the leader of natural cosmetic ingredients for sensitive skin.
Recombinant Collagen, also known as humanized collagen III, is a highly active biological raw material with 100% homology to the amino acid sequence of the functional domain of natural human skin type III collagen. It is a benchmark raw material in the global high-end skincare and cosmetics medicine industry. Plamed adopts genetic engineering recombination technology to obtain high-purity and high-activity recombinant collagen through high-density fermentation and separation and purification. It has dual structural confirmation: 100% peptide sequence coverage + consistent terminal amino acid sequence, fully retaining the native repair and anti-aging activity of type III collagen. Through precise sequence design, it achieves excellent water solubility of ≥100mg/ml and efficient skin penetration, with outstanding biocompatibility and skin repair functions. Meanwhile, an medicine cosmetics-grade extreme control system for bacterial endotoxin is established, reaching the industry-leading level of endotoxin <0.5EU/mg. The product features intact activity, controllable impurities, and strong batch stability, thoroughly solving industry pain points: traditional macromolecular collagen is difficult to be absorbed transdermally, and small molecular collagen peptides lack complete biological activity. It meets the regulatory filing and efficacy promotion requirements of major global markets. Recombinant Collagen specifically binds to integrin receptors on the cell surface and activates cell signaling pathways. It directly supplements type III collagen lost in the dermis of the skin, promotes the proliferation and migration of fibroblasts, and upregulates the gene and protein expression of type I/III collagen and elastin. It promotes the proliferation, migration and adhesion of keratinocytes, accelerating the healing of damaged skin wounds, and inhibits LPS-induced inflammatory response, significantly downregulates the release of pro-inflammatory factors, and alleviates the skin inflammatory cascade. It has the effects of barrier repair, anti-aging and wrinkle reduction, anti-inflammatory and soothing, deep moisturizing, and acne-prone skin repair. Cosmetics added with this raw material can improve problems such as damaged skin barrier, sensitive redness, dry fine lines, sagging, acne and acne marks, restoring the skin to a strong, hydrated and firm healthy state. It is widely used in sensitive skin repair, post-aesthetic treatment repair, high-end anti-aging, and infant skincare products.
| Product Name | CAS Number | INCI Name | |
| Recombinant Collagen | 9007-34-5 | SOLUBLE COLLAGEN | |
| Molecular Weight | Molecular Formula | Molecular Structure | |
| C1969H3088N664O675S4 | 47kDa |  |
|
| Product ID | Specification | Minimal Package | MOQ |
| PMKZ2601 | Purity≥ 90.0% | 10g | 10g |
Collagen for cosmetics is mainly divided into three categories: animal-derived extracted collagen, hydrolyzed collagen peptides, and genetically recombinant humanized collagen. Plamed recombinant collagen III—is the gold-standard raw material in the global high-end cosmetics filed, with the best compliance, safety and activity performance.
| Recombinant Collagen | Animal-Derived Extracted Collagen | Hydrolyzed Collagen Peptides (Small Molecular Peptides) | |
| Source & Preparation | Genetic engineering technology, prepared by aseptic fermentation, precise purification and freeze-drying; full sequence 100% homologous to human collagen III | Animal tissues such as bovine/porcine skin and fish scales, prepared by enzymatic hydrolysis, extraction and deodorization | Small molecular peptides below 1000Da |
| Preparation Process | Raw materials-Biosynthesis- Microfiltration-Ultrafiltration- Column Chromatography- Ultrafiltration-Column Chromatography-Freeze-Drying- Packaging | Animal tissue pretreatment -Acid/enzymatic extraction -Salting-out purification- Refining | Animal-derived collagen- Strong acid/strong alkali/enzymatic hydrolysis -Hydrolysis preparation |
| Advantages | 100% humanized sequence: completely consistent amino acid sequence with human type III collagen via genetic design, no immunogenicity risk;
Dual confirmation: 100% peptide sequence coverage + terminal amino acid sequence consistency, fully retaining natural activity; Ultra-low endotoxin: <0.5EU/mg, far better than cosmetic grade, suitable for hypersensitive and repair products; Stable batches: controllable fermentation process, no animal-derived pollution risk; Excellent solubility: ≥100mg/ml |
Relatively low cost
Natural source |
Small molecular weight, transdermal |
| Disadvantages | High technical requirements and large R&D investment, high cost | Molecular weight of hundreds of thousands of Daltons, cannot penetrate the skin; high raw material quarantine requirements, high filing risk; immunogenicity and animal-derived virus risks, significant batch differences, uncontrollable quality. | No complete activity, unable to claim collagen repair and anti-aging efficacy, limited claims; large fluctuations in hydrolysis process, large batch activity differences. |
| TEST ITEMS | SPECIFICATION |
| Purity | ≥90.0% HPLC |
| Content | ≥90.0% |
| Formula weight | 47kDa |
| Peptide sequence coverage | Should be 100% |
| Terminal amino acid sequence | Should be consistent with theory |
| Organoleptic | |
| Appearance | Powder or spongy solid |
| Color | White to off-white |
| Odor | Characteristic |
| Physical Characteristics | |
| pH value | 4.5 ~ 7.0 |
| Solubility | ≥100mg/ml |
| Loss on drying | ≤10.0% |
| Ignited residue | ≤2.0% |
| Heavy Metal | |
| Pb | ≤1ppm |
| As | ≤0.1ppm |
| Hg | ≤0.1ppm |
| Cd | ≤0.1ppm |
| Cr | ≤2ppm |
| Methanol | ≤100 ppm |
| Bacterial endotoxin | <0.5EU/mg |
| Microorganism Test | |
| Total plate count | ≤100 cfu/g |
| Yeast & mold count | ≤10 cfu/g |
| Pseudomonas aeruginosa | Not detected |
| Staphylococcus aureus | Not detected |
| Heat-resistant escherichia coli | Not detected |
Recombinant collagen III is the core structural protein of the skin dermis, known as the “wound repair collagen”. It achieves efficient barrier repair through multi-dimensional mechanisms:
Directly supplements collagen III lost with age, providing structural support for the skin. In vitro studies show it significantly promotes the proliferation, migration and adhesion of human keratinocytes, which is the cellular basis for accelerating epidermal wound healing and defect repair.
Also, it strengthens the skin barrier function, reduces transepidermal water loss (TEWL), and enhances skin resistance to external stimuli. Animal experiments confirm it effectively accelerates mucosal (analogous to skin barrier) injury healing and reduces inflammatory factor release. It can promotes healthy synthesis and arrangement of extracellular matrix, repairs the dermal-epidermal junction, and strengthens the skin barrier structure fundamentally.
Skin aging is marked by significant loss and structural disorder of type III collagen in the dermis. Recombinant collagen fights aging through synergistic effects: directly supplements collagen III, promotes fibroblasts to synthesize more endogenous type I/III collagen and elastin, increasing dermal density and thickness, filling static lines and improving sagging. It also have defense mechanism: excellent free radical scavenging ability, resists UV-induced oxidative stress, and protects collagen fibers from damage.
Studies show composites based on humanized collagen III significantly promote fibroblast proliferation and inhibit inflammatory response by downregulating TNF-α, IL-1β, etc., create a favorable microenvironment for collagen synthesis, thus overall improving skin elasticity and firmness. A randomized controlled clinical study on facial skin rejuvenation confirms that recombinant collagen III significantly improves wrinkles, texture and other aging signs.
This collagen has the potential to soothe sensitive skin and reduce inflammatory response through multiple targets: At the cellular level: collagen III effectively inhibits LPS-induced inflammatory response, significantly downregulates the expression of pro-inflammatory factors (e.g., TNF-α, IL-1β, IL-6) and upregulates anti-inflammatory factor IL-10, quickly relieving redness, stinging and other discomforts. In application, it is proven to reduce tissue inflammation and pain in animal models.
Collagen peptide chains are rich in hydrophilic groups, with excellent moisturizing properties. Plamed product achieves long-lasting moisturizing through dual pathways: forms a water-retaining film on the skin surface to relieve dryness instantly; repairs the barrier to fundamentally reduce water loss. More importantly, it solves the contradiction between activity and transdermal absorption. Traditional animal collagen has large molecular weight and poor absorption; small molecular collagen peptides may lose 3D active structure. Through precise genetic engineering design, our company produces recombinant collagen III fragments with a molecular weight of 47kDa and complete functional domains. This structure retains key active sequences for cell adhesion and repair, forms a stable triple helix structure with high thermal stability, ensuring high biological activity. Meanwhile, the appropriate molecular weight endows it with good water solubility and skin penetration potential, effectively acting on the dermis transdermally, realizing the leap from “surface moisturizing” to “deep repair”.
Recombinant collagen has excellent water solubility and transdermal absorption capacity, widely used in functional skincare products such as: sensitive skin repair serums/creams, post-aesthetic treatment repair lyophilized powders/gels, high-end anti-aging and wrinkle reduction serums/creams, infant moisturizing and repair products, gentle acne repair products, hydrating and moisturizing masks/emulsions. It is the core raw material in the global high-end cosmetic repair and anti-aging industry.
| Product | Reference Dosage |
| Recombinant Collagen (Purity ≥90.0%) | 0.01-0.2% |
Notes:
Recombinant Collagen Application in Cosmetics Worldwide
| Country | Brand | Product |
| China | COLLGENE | Recombinant Collagen Lifting & Anti-Wrinkle Essence Cream |
| PROYA | Energizing Fresh Anti-Wrinkle Firming Nourishing Cream | |
| Japan | ELIXIR | SUPERIEUR Lifting & Firming Renewing Cream |
| Cosme Decorte | Multi Protection Sunscreen | |
| IPSA | THE TIME RESET AQUA CLEAR GEL | |
| USA | Estée Lauder | Swiss Performing Extract |
| Elizabeth Arden | NEW YORK Flawless Start Hydrating Serum Primer | |
| France | Lancôme | Renergie Multi-Lift Lifting Firming Cream |
| L’Oréal Paris | Collagen Moisture Filler Daily Moisturizer Day/Night Cream | |
| Sisley | NIGHT CREAM WITH COLLAGEN AND WOODMALLOW ALL SKIN TYPES |
Package: 10g bottle packaging, with a sterile aluminum foil seal inside the bottle mouth.
Storage: Store in cool and dry place at temperature 2 to 8℃, keep away from strong light. Use it as soon as possible after unpacking.
Plamed focuses on natural cosmetic ingredients for more than 10 years. We have founded four subsidiary companies, which respectively develops different kinds of cosmetic raw material. Plamed is a company whose CEO is designated as the first secretary general of Shaanxi Plant Extraction Association.
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