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Honokiol

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Honokiol

Honokiol

  • Plamed owns mangnolia officinalis planting base, which can assure to supply Honokiol stably.
  • Plamed Honokiol’s solvent residue is lower compared to other factories. And it is less irritation to skin.
Where to buy Honokiol Powder with lowering Honokiol price and high quality? Where to find good information of Wholesale Honokiol and Purchase Honokiol for sales? As the professional Honokiol manufacturer, Plamed is your best choice.

Honokiol is a polyphenol compound. It naturally exists in dry bark and root of magnolia officinalis. Honokiol and its isomer Magnolol both are present in Chinese medicine magnolia officinalis. It not only has a variety of pharmacological activities, but also has good bioactivities for skin care. Honokiol can improve immune ability of skin cells, and has anti-inflammatory effect. Also Honokiol has a broad antibacterial spectrum. It can resist acid bacteria, and also exhibit inhibitory effect on gram-negative bacteria. Thus Honokiol can be used in prevention and treatment of acne. In addition, Honokiol plays an important role in anti-caries and inhibiting tooth decay in oral hygiene products. Honokiol is found to have activity as an antioxidant and skin whitening agent. At present, as a new natural cosmetic raw material, Honokiol is widely applied in anti-acne, whitening and anti-oxidation skin care products.

Product Name CAS Number INCI Name
Honokiol 35354-74-6 HONOKIOL
Molecular Formula Molecular Weight Molecular Structure
C18H18O2 266.33g/mol
Product ID Specificcation Minimal Package Minimal Order Quantity
PMQD0201 98% 1KG 1KG

Magnolia officinalis (Latin name: Magnolia officinalis Rehd. Et Wils.) is a deciduous tree of the genus Magnolia. In summer, it grows white flowers with fragrant scent. It is mainly distributed in the warm, moist and fertile mountain slopes at an altitude of 300-1500m. Magnolia officinalis can be found in Yangtze river basin of China, and also in Shaanxi and Gansu provinces. It is a rare and endangered species in China. Chinese medicine magnolia officinalis refers to its dry bark and root. Magnolia officinalis, as a kind of traditional and aromatic Chinese medicine, has great pharmacological effect. In recent years, there are increasing studies on magnolia at home and abroad. The application of magnolia extract (mainly known as Magnolol and Honokiol) with new effects has been continuously explored in cosmetics field.

Product Name Specification
Honokiol 98% HPLC

 

Items Specification
Assay ≥98.00%
Color White fine powder
Odor Characteristic
Taste Characteristic
Extract Solvent Water & ethanol
Part used Bark
Physical Characteristics
Particle Size 98% through 80 mesh
Moisture ≤1.00%
Ash content ≤1.00%
Bulk density 50-60g/100ml
Solvent Residue Eur. Pharm
Heavy Metals
Heavy metals ≤10ppm
Arsenic ≤2ppm
Plumbum ≤2ppm
Microbiological Tests
Total Plate count ≤1000cfu/g
Yeast & mold ≤100cfu/g
Escherichia coli Negative
Staphylococcus Negative
Salmonella Negative

Honokiol Chromatogram

  • Anti-bacterial

Honokiol has a broad anti-bacterial spectrum. Its antibacterial property is stable, and it’s not easy to be damaged by heat, acid, alkali. Some scholars have found that Honokiol has a strong inhibitory effect on streptococcus mutans. The result shows that it has good antibacterial effect on staphylococcus aureus; and its MIC is 6.25μg/mL. Therefore, Honokiol can be added into cosmetics to treat acne, and can also be used as a natural preservative of cosmetics.

  • Anti-acne and anti-inflammation

Honokiol has strong inhibitory effect on P.acnes and P.granulosum that can lead to acne. The MIC is 9mg/L. Furthermore, it can effectively reduce the increase of THP-1cell, IL-8 and TNF-αcaused by P.acnes. So it proves that Honokiol can treat local skin inflammation.

  • Anti-aging and whitening

Study has shown that Honokiol can enhance activity of antioxidant enzymes such as SOD, CAT and GSH2Px in serum and tissues of mice; and it can lower the content of MDA, a lipid peroxide in the body. Under the action of Honokiol, antioxidant capacity of human body has been improved. And excessive free radicals produced by aging body can be quickly eliminated. Thereby, further chain reaction of oxygen free radical is blocked, and per-oxidation process of tissues and cells is inhibited. Thus Honokiol can exert its anti-aging effect. Moreover, the scavenging capacity of Honokiol on free radicals is stronger than that of classic antioxidant ascorbic acid. And Honokiol can also inhibit tyrosinase activity; so it has certain whitening function, and can be used in cosmetics as skin whitening agent.

Test Item Concentration Result
Elimination to hydroxyl radicals 0.2mmol/L Elimination rate: 82.5%
Elimination to free radical DPPH 50μmol/L Elimination rate: 23.6%
Inhibition to unsaturated fatty acid peroxidation 0.2mmol/L Inhibition rate: 85.8%
Inhibition to tyrosinase activity 0.01% Inhibition rate: 38.8%
Inhibition to NF-kB cell activity 20μmol/L Inhibition rate: 20.4%
Inhibition to metalloproteinase MMP-1 activity 10μmol/L Inhibition rate: 18.2%

Honokiol is widely used in cosmetics and other daily chemicals:

  • Dental products (toothpaste, mouth wash) for prevention of gingivitis; recommended dosage is 0.3%. As a natural preservative in cosmetics.
  • Anti-pimple and anti-acne facial essence, lotion, cream, etc;
  • As anti-aging and whitening agent in sunscreen, cleanser, mask and other skin care products.

Honokiol application cases in major cosmetic brands in the world:

Country Brand Product
Switzerland L‘ADMIRER Beauty Plus Defensil Concentrate
SURPUR Radiant Day Cream
Thailand VLanse Milk Bath Cream 

Q10 Skin Refining and Whitening Scrub

Q10 Facial Foam
German NIVEA Cell Ular Anti-Age Eye Cream
France Sa[è]ve Firming and Repairing Essence 

Moisturizing Emulsion

Moisturizing Day Cream

Firming and Repairing Night Cream
UAS Richme Day Facial Cream
Estee Lauder Re-nutriv Ultimate Diamond Transformative Energy Eye Cream

Natural plant moisturizing toner

Ingredient Content(%) Ingredient Content(%)
Honokiol 5 Corn Propylene Glycol 8
Glycerin 8 Dioscorease Rhizome Extract 5
Sodium Hyaluronate 0.06 Fructus Momordicae Extract 5
Water Add to 100 Chinese Angelica Extract 5
Indian Buead Extract 5 Aloe Barbadensis Leaf Extract 5

Honokiol Safety

  • Cosmetic, Toiletry & Fragrance Association (CTFA) has specified Honokiol as a cosmetics ingredient.
  • Honokiol is listed on The International Catalogue of Chinese Cosmetic Raw Materials Standards in 2010 issued by CAFFCI and On the Announcement of Name List of Cosmetics Raw Material published by CFDA in 2014. No reports show its insecurity.

Packing and Storage

Package: Packed in 25kg paper drums with two plastic bags inside.

Storage: Stored in a cool dry place and away from direct sunlight and oxidizing agents.

1. Honokiol VS. Magnolol for Skin Benefits

2. Magnolia Officinalis Bark Extract Introduction

3. Magnolol Introduction

4. Magnolia Bark Extract Introduction

Plamed focuses on natural cosmetic ingredients for more than 10 years. We have founded four subsidiary companies, which respectively develops different kinds of cosmetic raw material. Plamed is a company whose CEO is designated as the first secretary general of Shaanxi Plant Extraction Association.

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